My PROLASTIN®-C LIQUID (alpha1-proteinase inhibitor [human]) means a treatment in step with my life.

“PROLASTIN-C LIQUID has made a difference to me.”

—Jesus, actual patient since 2016

PROLASTIN-C LIQUID is the #1 prescribed augmentation therapy, trusted by alpha-1 patients and their doctors for more than 35 years.1

What is PROLASTIN-C LIQUID?

A proven treatment

PROLASTIN-C LIQUID has been clinically demonstrated to effectively raise alpha1 antitrypsin protein levels in patients with alpha1-antitrypsin deficiency.2

A trusted treatment

As the augmentation therapy leader, PROLASTIN-C LIQUID has been the #1 prescribed augmentation therapy for more than 35 years.1

A treatment in step with life

Weekly infusions with PROLASTIN-C LIQUID may be administered by a healthcare professional at home, at work, at an infusion center, or even when you are traveling.

A treatment with unmatched support

Patients receiving treatment with PROLASTIN-C LIQUID are automatically enrolled in PROLASTIN DIRECT®. This program helps patients get started on treatment and find meaningful support.

Heather, actual patient since 2018

Important facts about treatment with PROLASTIN-C LIQUID.

  • PROLASTIN-C LIQUID is an alpha1-proteinase inhibitor (human) (alpha1-PI) indicated for chronic augmentation and maintenance therapy in adults with clinical evidence of emphysema due to severe hereditary deficiency of alpha1-PI (alpha1-antitrypsin deficiency)
  • Effects of PROLASTIN-C LIQUID on worsening lung function and emphysema progression have not been proven in clinical trials. Clinical data on the long term effects of augmentation therapy and maintenance therapy with PROLASTIN-C LIQUID are not available. PROLASTIN-C LIQUID is not meant to be used as a therapy for lung disease where severe alpha1-antitrypsin deficiency has not been established
  • Treatment with PROLASTIN-C LIQUID involves a lifelong weekly infusion, which takes about 15 minutes at the recommended rate (0.08 mL/kg/min)
  • PROLASTIN-C LIQUID is contraindicated in patients with IgA deficiency and antibodies against IgA due to the risk of severe hypersensitivity and in patients with a history of anaphylaxis or other severe systemic reactions to alpha1-PI
  • The most common adverse reactions during PROLASTIN-C LIQUID clinical trials in >5% of subjects were diarrhea and fatigue, each of which occurred in 2 subjects (6%)

How PROLASTIN-C LIQUID works

PROLASTIN-C LIQUID contains a purified form of alpha₁ antitrypsin protein, derived from human plasma (the fluid part of blood). It raises alpha1 antitrypsin protein levels in patients with alpha1-antitrypsin deficiency.2 Watch the video below to see how PROLASTIN-C LIQUID works at a cellular level.

Getting started with PROLASTIN-C LIQUID

Prescription is sent

Your doctor sends your prescription to the PROLASTIN DIRECT program, which helps you with choosing where to receive infusions, navigating insurance coverage, and more.

Representative calls

PROLASTIN DIRECT will call you within 48 hours after receiving your prescription. A representative will verify your insurance, answer any questions you may have, and help complete your prescription processing.

Infusion location set

If you would like to receive infusions at home, a nurse from PROLASTIN DIRECT will call to review and confirm your insurance coverage and benefits. They’ll also explain how the program, treatment, and infusion work, and how your medication will be sent. If you choose infusions at an infusion center, the center will call to explain their process.

There’s more to know.

  • It is very important to answer the phone call to get your treatment started. The caller ID may show as “unknown” or “NA” or even “Accredo,” the name of a specialty pharmacy.
  • PROLASTIN DIRECT can even help you connect with an AlphaNet Coordinator trained to help patients receiving PROLASTIN-C LIQUID.
  • Not prescribed and considering treatment? Get helpful guidance for starting the conversation with your doctor.

Receiving your PROLASTIN-C LIQUID treatment

Shipment and storage of PROLASTIN-C LIQUID

  • Every month the specialty pharmacy that fills prescriptions for PROLASTIN-C LIQUID, will call you to check on supplies and confirm shipment
  • Whether you infuse at home or at an infusion center, your shipment will arrive on time
  • Your PROLASTIN-C LIQUID will ship in refrigerated packs
  • Store refrigerated at 36-46°F (2-8°C) for the period indicated by the expiration date on its label. Product may be stored at room temperatures not exceeding 77°F (25°C) for up to one month, after which the product must be used or immediately discarded. Do not freeze

Dosing and administration of PROLASTIN-C LIQUID2

  1. The recommended dose of PROLASTIN-C LIQUID is 60 mg/kg of body weight infused intravenously once per week
  2. You can receive PROLASTIN-C LIQUID at a rate of up to 0.08 milliliters for each kilogram per minute
  3. The average infusion takes about 15 minutes when given at the recommended rate of 0.08 mL/kg/min

Toya and Jesus, actual patients

The PROLASTIN DIRECT program helps patients get started and stay supported.

Learn More

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Important Safety Information

PROLASTIN®-C LIQUID is an alpha1-proteinase inhibitor (human) (alpha1-PI) indicated for chronic augmentation and maintenance therapy in adults with clinical evidence of emphysema due to severe hereditary deficiency of alpha1-PI (alpha1-antitrypsin deficiency).

Limitations of Use

  • The effect of augmentation therapy with any alpha1-PI, including PROLASTIN-C LIQUID, on pulmonary exacerbations and on the progression of emphysema in alpha1-PI deficiency has not been conclusively demonstrated in randomized, controlled clinical trials
  • Clinical data demonstrating the long-term effects of chronic augmentation or maintenance therapy with PROLASTIN-C LIQUID are not available
  • PROLASTIN-C LIQUID is not indicated as therapy for lung disease in patients in whom severe alpha1-PI deficiency has not been established

PROLASTIN-C LIQUID is contraindicated in immunoglobulin A (IgA)-deficient patients with antibodies against IgA or patients with a history of anaphylaxis or other severe systemic reaction to alpha1-PI products.

Hypersensitivity reactions, including anaphylaxis, may occur. Monitor vital signs and observe the patient carefully throughout the infusion. If hypersensitivity symptoms occur, promptly stop PROLASTIN-C LIQUID infusion and begin appropriate therapy.

Because PROLASTIN-C LIQUID is made from human plasma, it may carry a risk of transmitting infectious agents, eg, viruses, the variant Creutzfeldt-Jakob disease (vCJD) agent, and, theoretically, the Creutzfeldt-Jakob disease (CJD) agent. This also applies to unknown or emerging viruses and other pathogens.

The most common adverse reactions during PROLASTIN-C LIQUID clinical trials in >5% of subjects were diarrhea and fatigue, each of which occurred in 2 subjects (6%).

Please see full Prescribing Information for PROLASTIN-C LIQUID.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit http://www.fda.gov/medwatch, or call 1-800-FDA-1088.

References

  1. Data on file, Grifols.
  2. PROLASTIN®-C LIQUID (alpha1-proteinase inhibitor [human]) Prescribing Information. Grifols.