Starting or considering treatment with PROLASTIN-C LIQUID?
Ready to move forward on your alpha-1 treatment journey? The tools and resources you need are right here. You’ll find answers to the most common questions about PROLASTIN-C LIQUID and links to important resources. If you still have more questions about alpha-1 or treatment options, ask your doctor.
What could PROLASTIN-C LIQUID mean to you?
Get the essential guides to PROLASTIN-C LIQUID and the PROLASTIN DIRECT® program.
PROLASTIN-C LIQUID Patient Brochure
PROLASTIN DIRECT Program Brochure
Frequently asked questions about PROLASTIN-C LIQUID
Not every doctor is an expert in alpha-1. Your primary care physician may need to refer you to other healthcare professionals who specialize in alpha-1 care for diagnosis and treatment, like pulmonologists and genetic counselors. Your primary care physician may also play a role in the day-to-day management of your alpha-1.
PROLASTIN-C LIQUID is a concentrated form of the alpha₁ antitrypsin protein that is purified from human blood plasma. PROLASTIN-C LIQUID has been proven to effectively raise alpha₁ antitrypsin protein levels in people with alpha₁-antitrypsin deficiency.
Yes, PROLASTIN-C LIQUID is a biologic, a kind of medication produced from living plant or animal cells. PROLASTIN-C LIQUID is purified from human blood plasma.
Because PROLASTIN-C LIQUID “augments” or replaces the missing alpha₁ antitrypsin protein, it is referred to as “augmentation therapy.” PROLASTIN-C LIQUID is an augmentation therapy for treatment of adults with clinical evidence of emphysema due to severe hereditary deficiency of alpha₁-proteinase inhibitor.
PROLASTIN-C LIQUID raises alpha₁ antitrypsin protein levels in patients with alpha₁-antitrypsin deficiency. Watch a video to see how PROLASTIN-C LIQUID works.
PROLASTIN-C LIQUID is a concentrated form of the alpha₁ antitrypsin protein that is purified from human blood plasma. Grifols maintains the largest network of plasma donation centers in the US and globally to help ensure a consistent supply. Just one plasma donation can help treat a wide range of diseases.
Because PROLASTIN-C LIQUID is made from human blood plasma, it may carry a risk of transmitting infectious agents like viruses. The good news is that PROLASTIN-C LIQUID is manufactured using a special purification and testing process to help minimize these risks.
The most common adverse reactions during PROLASTIN-C LIQUID clinical trials in >5% of subjects were diarrhea and fatigue, each of which occurred in 2 subjects (6%).1
Only your doctor can decide the right treatment for you. It’s normal to have questions about your diagnosis and possible treatment options. Get help preparing for your next appointment with a special guide for talking with your doctor.
The PROLASTIN DIRECT program is a comprehensive patient support program that provides you with a team dedicated to alpha-1 care, who will assist you with securing insurance coverage, coordinating infusions, and connecting you to AlphaNet®. PROLASTIN DIRECT will work with the specialty pharmacy to help you receive your treatment. Learn more in the questions below.
AlphaNet is a not-for-profit organization of Alphas Serving Alphas®, where patients with alpha-1 can get the support they need from someone who knows exactly what they are going through. These expert AlphaNet Coordinators are devoted to helping improve the lives of alphas receiving treatment with PROLASTIN-C LIQUID, and provide support through monthly follow-up phone calls. PROLASTIN DIRECT can help connect you with an AlphaNet Coordinator. Watch a video to learn how AlphaNet can help you at every stage of your alpha-1 journey.
Accredo is a specialty pharmacy that fills and ships PROLASTIN-C LIQUID prescriptions. Accredo also manages the PROLASTIN DIRECT program.
PROLASTIN-C LIQUID is distributed by a specialty pharmacy that fills and ships PROLASTIN-C LIQUID prescriptions and manages the PROLASTIN DIRECT program. Once the PROLASTIN DIRECT team receives your prescription from your doctor, you will receive a phone call within 48 hours. Your caller ID may display "Unknown Caller," "Unavailable Caller," or 833-PHONEA1 (833-746-6321). It is important you answer the phone so they can walk you through the process, explain your benefits, and answer your questions.
PROLASTIN-C LIQUID is shipped directly from a specialty pharmacy in refrigerated packs. PROLASTIN-C LIQUID should be stored in the refrigerator at 36 °F to 46 °F (2 °C to 8 °C) for the period indicated by the expiration date on its label. It may be stored at room temperatures not exceeding 77 °F (25 °C) for up to one month, after which the product must be used or immediately discarded. Do not freeze.
PROLASTIN-C LIQUID involves a weekly infusion that takes approximately 15 minutes when given at the recommended rate of 0.08 mL/kg/min.1
There is no latex in the PROLASTIN-C LIQUID treatment or its packaging. The vial stopper is latex-free.
You can take comfort in knowing that the PROLASTIN DIRECT program works directly with your insurance company to secure and coordinate your infusion location. This may be at home, at an infusion center, or even when you are traveling. If you receive your infusions at home, your PROLASTIN-C LIQUID will be delivered directly to your home prior to your appointment with your infusion nurse. If you go to an infusion center, your PROLASTIN-C LIQUID will be waiting for you when you get there.
If you prefer, and depending on your insurance, you may be able to receive infusions at home from an infusion nurse. The specialty pharmacy can also help coordinate your shipments when you’re traveling. Talk with your doctor or call PROLASTIN DIRECT at 833-PHONEA1 (833-746-6321) for more help.
You’re never alone. There are others on the path with you.
What is treatment with PROLASTIN-C LIQUID like? See three real patients share their stories.
Important Safety Information
PROLASTIN®-C LIQUID is an alpha1-proteinase inhibitor (human) (alpha1-PI) indicated for chronic augmentation and maintenance therapy in adults with clinical evidence of emphysema due to severe hereditary deficiency of alpha1-PI (alpha1-antitrypsin deficiency).
Limitations of Use
- The effect of augmentation therapy with any alpha1-PI, including PROLASTIN-C LIQUID, on pulmonary exacerbations and on the progression of emphysema in alpha1-PI deficiency has not been conclusively demonstrated in randomized, controlled clinical trials
- Clinical data demonstrating the long-term effects of chronic augmentation or maintenance therapy with PROLASTIN-C LIQUID are not available
- PROLASTIN-C LIQUID is not indicated as therapy for lung disease in patients in whom severe alpha1-PI deficiency has not been established
PROLASTIN-C LIQUID is contraindicated in immunoglobulin A (IgA)-deficient patients with antibodies against IgA or patients with a history of anaphylaxis or other severe systemic reaction to alpha1-PI products.
Hypersensitivity reactions, including anaphylaxis, may occur. Monitor vital signs and observe the patient carefully throughout the infusion. If hypersensitivity symptoms occur, promptly stop PROLASTIN-C LIQUID infusion and begin appropriate therapy.
Because PROLASTIN-C LIQUID is made from human plasma, it may carry a risk of transmitting infectious agents, eg, viruses, the variant Creutzfeldt-Jakob disease (vCJD) agent, and, theoretically, the Creutzfeldt-Jakob disease (CJD) agent. This also applies to unknown or emerging viruses and other pathogens.
The most common adverse reactions during PROLASTIN-C LIQUID clinical trials in >5% of subjects were diarrhea and fatigue, each of which occurred in 2 subjects (6%).
Please see full Prescribing Information for PROLASTIN-C LIQUID.
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit http://www.fda.gov/medwatch, or call 1-800-FDA-1088.
References
- PROLASTIN®-C LIQUID (alpha1-proteinase inhibitor [human]) Prescribing Information. Grifols.