resources - prolastin-c

PROLASTIN®-C LIQUID and Alpha-1 Resources

If you or a loved one has been recently diagnosed with alpha1-antitrypsin deficiency, we realize you may have some questions. In addition to having conversations with your doctor, the resources below can provide you with the helpful information you need to answer those questions, so you can feel confident that support is here for you.


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Download or print these materials about PROLASTIN-C LIQUID


This brochure provides helpful information about PROLASTIN-C LIQUID, the #1 prescribed augmentation therapy trusted by patients with alpha-1 and their doctors for more than 25 years.1


PROLASTIN DIRECT® Program Brochure

This brochure explains all the benefits and services provided through the PROLASTIN DIRECT program, a comprehensive support program that gives you the confidence that ongoing personalized support is there for you when you need it.



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Frequently asked questions about

PROLASTIN-C LIQUID is augmentation therapy for treatment of adults with clinical evidence of emphysema due to severe hereditary deficiency of alpha1-proteinase inhibitor. PROLASTIN-C LIQUID has been proven to effectively raise the levels of the alpha1-antitrypsin protein in your blood. It comes in a ready-to-use, concentrated form of alpha1-antitrypsin protein.2

PROLASTIN-C LIQUID is only distributed by EVERSANA. EVERSANA is the only specialty pharmacy that fills and ships PROLASTIN-C LIQUID prescriptions, and manages the PROLASTIN DIRECT program. Once the PROLASTIN DIRECT team receives your prescription from your doctor, you will receive a phone call within 24 hours. Your caller ID may display "Unknown Caller," "Unavailable Caller," or "800-305-7881." It is important you answer the phone so they can walk you through the process, explain your benefits, and answer any of your questions. 

PROLASTIN-C LIQUID is shipped directly from the specialty pharmacy, EVERSANA, in refrigerated packs. PROLASTIN-C LIQUID should be stored in the refrigerator at 36-46oF (2-8oC) for the period indicated by the expiration date on its label. It may be stored at room temperatures not exceeding 77oF (25oC) for up to one month, after which the product must be used or immediately discarded. Do not freeze.

No, the PROLASTIN-C LIQUID vial stopper is latex free.

You can take comfort in knowing that the PROLASTIN DIRECT program works directly with your insurance company to secure and coordinate your infusion location. This may be at home, at work, at an infusion center, or even when you are traveling. If you receive your infusions at home, your PROLASTIN-C LIQUID will be delivered directly to your home prior to your appointment with your infusion nurse. If you go to an infusion center, your PROLASTIN-C LIQUID will be waiting for you when you get there.

PROLASTIN-C LIQUID involves a weekly infusion that takes approximately 15 minutes when given at the recommended rate of 0.08 mL/kg/min.2

The PROLASTIN DIRECT program is a comprehensive patient support program that provides you with a team dedicated to alpha-1 care, who will assist you with securing insurance coverage, coordinating infusions, and connecting you to AlphaNet®.

EVERSANA is a specialty pharmacy, and is the only pharmacy that fills and ships PROLASTIN-C LIQUID prescriptions. EVERSANA also manages the PROLASTIN DIRECT® program.

AlphaNet is a not-for-profit organization of Alphas Serving Alphas®, where patients with alpha-1 can get the support they need from someone who knows exactly what they are going through. These expert AlphaNet Coordinators are devoted to helping improve the lives of alphas receiving treatment with PROLASTIN-C LIQUID, and provide support through monthly follow-up phone calls.

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resources - alpha-1

Connecting you to helpful support organizations

These are external third-party organizations dedicated to helping people with Alpha-1 and learning about their conditions.

Alpha-1 Foundation logo

Alpha-1 Foundation
Toll-free: (877) 228-7321

The Alpha-1 Foundation is the only national organization dedicated to developing a cure for alpha-1 and to improving the quality of life for patients and their families. Acting as a patient advocate, the foundation helps those in the alpha-1 community better connect to one another—strengthening the support and care networks they need.

To find an Alpha-1 Foundation Clinical Resource Center (CRC) that specializes in patient care, education, and research for alpha-1, Click Here

The Alpha-1 Foundation offers a variety of resources for patients with alpha-1 and their family members.

What is Alpha-1?

What is Alpha-1? (Spanish translation)

Alpha-1 Antitrypsin Deficiency: A Guide for the Recently Diagnosed Individual

Am I an Alpha-1 Carrier?

Alpha-1 Antitrypsin Deficiency: It's All in the Family

Alpha-1 Foundation Genetic Counseling Program

AlphaNet logo

Toll Free: (800) 577-2638

AlphaNet is a not-for-profit health management company providing comprehensive services exclusively to the alpha-1 community via care coordinators who are patients with alpha-1 themselves.

This listing is provided as a resource only. Grifols does not review or control the content of non-Grifols websites.


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PROLASTIN-C Liquid trusted by patients with alpha-1 and their doctors icon

PROLASTIN-C LIQUID: The trusted leader for more than 25 years

PROLASTIN-C LIQUID is the #1 prescribed augmentation therapy, trusted by patients with alpha-1 and their doctors for more than 25 years. More than 4 million PROLASTIN-C infusions have been performed around the world.1




PROLASTIN®-C LIQUID is an alpha1-proteinase inhibitor (human) (alpha1-PI) indicated for chronic augmentation and maintenance therapy in adults with clinical evidence of emphysema due to severe hereditary deficiency of alpha1-PI (alpha1-antitrypsin deficiency).

Limitations of Use

  • The effect of augmentation therapy with any alpha1-PI, including PROLASTIN-C LIQUID, on pulmonary exacerbations and on the progression of emphysema in alpha1-PI deficiency has not been conclusively demonstrated in randomized, controlled clinical trials
  • Clinical data demonstrating the long-term effects of chronic augmentation or maintenance therapy with PROLASTIN-C LIQUID are not available
  • PROLASTIN-C LIQUID is not indicated as therapy for lung disease in patients in whom severe alpha1-PI deficiency has not been established

PROLASTIN-C LIQUID is contraindicated in immunoglobulin A (IgA)-deficient patients with antibodies against IgA or patients with a history of anaphylaxis or other severe systemic reaction to alpha1-PI products.

Hypersensitivity reactions, including anaphylaxis, may occur. Monitor vital signs and observe the patient carefully throughout the infusion. If hypersensitivity symptoms occur, promptly stop PROLASTIN-C LIQUID infusion and begin appropriate therapy.

Because PROLASTIN-C LIQUID is made from human plasma, it may carry a risk of transmitting infectious agents, eg, viruses, the variant Creutzfeldt-Jakob disease (vCJD) agent, and, theoretically, the Creutzfeldt-Jakob disease (CJD) agent. This also applies to unknown or emerging viruses and other pathogens.

The most common adverse reactions during PROLASTIN-C LIQUID clinical trials in >5% of subjects were diarrhea and fatigue, each of which occurred in 2 subjects (6%).

Please see full Prescribing Information for PROLASTIN-C LIQUID.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit, or call 1-800-FDA-1088.


resources - references

References: 1. Data on file, Grifols. 2. PROLASTIN®-C LIQUID (alpha1-proteinase inhibitor [human]) Prescribing Information. Grifols.