Family Testing for Alpha-1
Alpha-1 is a genetic condition. Other members of your family may have the same gene pattern as you. The risk of having Alpha-1 or being a carrier for Alpha-1 is 3 out of 4 if both parents carry the Pi Z gene. If they are carriers for Alpha-1, they could pass it on without even knowing it.
Alpha-1 occurs when a person inherits one abnormal gene from each of his or her parents.
If tests indicate you are an Alpha-1 or a carrier: there are steps you can take to manage your disease, which may reduce your risk of lung disease. Early behavioral management may prevent deterioration of your lung function and reduce your risk of serious lung disease.
Healthcare providers and patients should discuss the advantages and disadvantages of testing before making a final decision.
- If one of the parents has two abnormal genes (i.e., is an Alpha or Pi ZZ type), then the child has a 100% chance of being a carrier.
- If each parent has only one abnormal gene (i.e., is an Alpha carrier), then the child has a 50% chance of being a carrier, a 25% chance of being an Alpha, and a 25% chance of having two normal alleles.
FREE TEST KIT
Up to 25 million Americans are estimated to carry an abnormal Alpha-1 gene1
Many of the estimated 25 million carriers for Alpha-1 have an increased risk of lung disease.1,2 Request a free AlphaKit at www.MyAlphaTest.com/pro-c