I know that PROLASTIN®-C LIQUID and the PROLASTIN DIRECT® program will be there for me, supporting me every step of the way
PROLASTIN-C LIQUID, the #1 prescribed alpha-1 therapy.1
What is alpha1-antitrypsin deficiency?
Alpha1-antitrypsin deficiency (alpha-1) is a rarely diagnosed genetic disease often called "genetic COPD" because it can be passed down through families. If you have alpha-1, your body does not make enough alpha1 antitrypsin, a protein that protects your lungs.2
Approximately 100,000 people in the United States have alpha-1, but more than 9 out of 10 don't know they have it.3
Recently diagnosed with alpha-1?
What is PROLASTIN-C LIQUID?
PROLASTIN-C LIQUID is the trusted leader for more than 30 years. You're offered the convenience of receiving your infusion at home, work, an infusion center, and even when you are traveling.
PROLASTIN-C LIQUID is an alpha1-proteinase inhibitor (human) (alpha1-PI) indicated for chronic augmentation and maintenance therapy in adults with clinical evidence of emphysema due to severe hereditary deficiency of alpha1-PI (alpha1-antitrypsin deficiency). PROLASTIN-C LIQUID is a ready-to-use formulation that has been proven to effectively raise the alpha1-antitrypsin protein levels in patients with alpha-1.4
PROLASTIN-C LIQUID is contraindicated in IgA-deficient patients with antibodies against IgA due to the risk of severe hypersensitivity and in patients with a history of anaphylaxis or other severe systemic reactions to alpha1-PI.
Talk to your doctor if PROLASTIN-C LIQUID is right for you.
Starting PROLASTIN-C LIQUID therapy
PROLASTIN-C LIQUID is the #1 prescribed augmentation therapy, trusted by patients with alpha-1 and their doctors for more than 30 years.1
What is the PROLASTIN DIRECT® program?
The PROLASTIN DIRECT program gives you the confidence that ongoing, personalized support is there for you when needed.
Program benefits
The PROLASTIN DIRECT program provides many benefits at no additional cost to you, including:
- Insurance verification and coordination
- Infusion coordination
- Pharmacy services, supplies, and delivery
- 24/7 access to alpha-1–expert nurses and pharmacists
Alpha-1 support team
Your PROLASTIN DIRECT program team includes a Patient Service Coordinator and alpha-1–expert nurses and pharmacists, exclusively dedicated to alpha-1 and to your care.
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Read more about all the benefits and services provided through the PROLASTIN DIRECT program.
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PROLASTIN-C LIQUID: The trusted leader for more than 30 years
PROLASTIN-C LIQUID is the #1 prescribed augmentation therapy, trusted by patients with alpha-1 and their doctors for more than 30 years. More than 4 million PROLASTIN-C infusions have been performed around the world.1
IMPORTANT SAFETY INFORMATION
PROLASTIN®-C LIQUID is an alpha1-proteinase inhibitor (human) (alpha1-PI) indicated for chronic augmentation and maintenance therapy in adults with clinical evidence of emphysema due to severe hereditary deficiency of alpha1-PI (alpha1-antitrypsin deficiency).
Limitations of Use
- The effect of augmentation therapy with any alpha1-PI, including PROLASTIN-C LIQUID, on pulmonary exacerbations and on the progression of emphysema in alpha1-PI deficiency has not been conclusively demonstrated in randomized, controlled clinical trials
- Clinical data demonstrating the long-term effects of chronic augmentation or maintenance therapy with PROLASTIN-C LIQUID are not available
- PROLASTIN-C LIQUID is not indicated as therapy for lung disease in patients in whom severe alpha1-PI deficiency has not been established
PROLASTIN-C LIQUID is contraindicated in immunoglobulin A (IgA)-deficient patients with antibodies against IgA or patients with a history of anaphylaxis or other severe systemic reaction to alpha1-PI products.
Hypersensitivity reactions, including anaphylaxis, may occur. Monitor vital signs and observe the patient carefully throughout the infusion. If hypersensitivity symptoms occur, promptly stop PROLASTIN-C LIQUID infusion and begin appropriate therapy.
Because PROLASTIN-C LIQUID is made from human plasma, it may carry a risk of transmitting infectious agents, eg, viruses, the variant Creutzfeldt-Jakob disease (vCJD) agent, and, theoretically, the Creutzfeldt-Jakob disease (CJD) agent. This also applies to unknown or emerging viruses and other pathogens.
The most common adverse reactions during PROLASTIN-C LIQUID clinical trials in >5% of subjects were diarrhea and fatigue, each of which occurred in 2 subjects (6%).
Please see full Prescribing Information for PROLASTIN-C LIQUID.
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit http://www.fda.gov/medwatch, or call 1-800-FDA-1088.
References: 1. Data on file, Grifols. 2. What is alpha-1? Alpha-1 Foundation website. https://www.alpha1.org/what-is-alpha1. Accessed August 2, 2022. 3. Campos MA, Wanner A, Zhang G, Sandhaus RA. Trends in the diagnosis of symptomatic patients with α1-antitrypsin deficiency between 1968 and 2003. Chest. 2005;128(3):1179-1186. 4. PROLASTIN®-C LIQUID (alpha1-proteinase inhibitor [human]) Prescribing Information. Grifols.