Effects of Smoking
Smoking accelerates lung function decline
Smoking Accelerates Lung Function Decline in Alpha-11
FEV1 is a lung function measurement which measures how much air you can breathe out in one second. It is a measure of lung health.
When lungs are irritated by tobacco smoke, your body produces neutrophil elastase to eliminate it from your lungs. When the neutrophil elastase has finished breaking down the tobacco smoke, it continues to work, destroying your lung tissue and reducing its ability to expand and contract.7
Your body responds by producing AAT to neutralize excess neutrophil elastase. If there is a shortage of AAT, neutrophil elastase continues to break down your lung tissue, leaving you with less lung function.7
In 1 clinical study of 927 patients with Alpha-1, 78.7% of patients were either current smokers (8.1%) or ex-smokers (70.6%)1
Cigarette smoke destroys delicate lung tissue5,6
As shown above, normal lung tissue which has small, regular sized openings (left) is destroyed by smoking, causing large openings that interfere with lung function (right) because of cigarette smoke,2,3 which:
- Contains oxidants capable of inactivating AAT2
- Recruits inflammatory cells and increases neutrophil elastase concentration8
- Can be detrimental to lung function,2,4 even as second-hand smoke
Learn how to quit smoking. Get information about quitting on the web site of the American Lung Association.
Help Alphas stay healthy. Download Managing Environmental Risk Factors, a brochure from AlphaNet that you can help you stay healthy.