If you’re an Alpha-1 carrier, you may or may not have these symptoms:5
Levels ≥ 11 µM AAT level are estimated to be protective
If you’ve been identified as an Alpha-1 carrier you do not necessarily need treatment. However, it is critical that other family members also get tested, since there is a chance your family members have severe Alpha-1 and do need treatment.
Also, you should have your levels of AAT checked periodically to ensure that you have a level sufficient to protect your lungs and liver. Talk to your doctor about the latest thinking on treatment options for Alpha-1 carriers.
Vaccinations are recommended for Alpha-1 carriers. You might not need the same treatment as someone with severe Alpha-1 but your lungs are vulnerable to pollutants and infections, and vaccines can help you protect them. Have a yearly flu vaccine and a Pneumovax® shot, which protects against certain infections, every 5 to 6 years. Ask your doctor if you need a vaccine for hepatitis A and B. These are especially important if you have established liver disease:5
Prolastin-C, Alpha1-Proteinase Inhibitor (Human) is for adults who have emphysema caused by inherited alpha1-antitrypsin deficiency. The effect of therapy with any alpha1-proteinase inhibitor (alpha1-PI) on pulmonary exacerbations and on the progression of emphysema in alpha1-antitrypsin deficiency has not been demonstrated in randomized, controlled clinical trials. PROLASTIN-C is not indicated as therapy for lung disease in patients in whom severe Alpha1-PI deficiency has not been established.
Prolastin-C may contain trace amounts of IgA. IgA deficient patients with antibodies against IgA should not receive Prolastin-C due to the risk of hypersensitivity.
The most common side effects during clinical trials with Prolastin-C were chills, a general feeling of being unwell, headache, rash, hot flush, and itching.
Prolastin-C is made from human plasma. Products made from human plasma may carry a risk of transmitting infectious agents, e.g., viruses, and, theoretically, the Creutzfeldt-Jakob disease (CJD) agent.
Please see accompanying Prolastin-C Full Prescribing Information for complete prescribing details.
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.