What do Alpha1 lungs look like?
CAT scan of alpha-1 deficient patient
Getting tested for Alpha-1 is easy. It is diagnosed with simple blood tests. Find out about a free Grifols AlphaKit you can get from your doctor.
Alpha-1 is a hereditary condition passed from parents to children through genes. If you have 1 abnormal gene instead of 2, you are a carrier for Alpha-1.
For the most part, there are 2 genes for each trait a person has. One gene comes from the mother, 1 from the father. People with Alpha-1 received 2 abnormal genes for making AAT, that is, the body’s instructions omitted the steps to produce and distribute AAT4.
AAT Blood Levels
|MM (2 normal copies)||20–53 µM/L||150–350 Mg/dL|
|MZ (1 normal copy, 1 abnormal copy)||12–28 µM/L||90–210 Mg/dL|
|SS (2 marginally abnormal copies)||13–27 µM/L||100–210 Mg/dL|
|SZ (1 abnormal copy,|
1 marginally abnormal copy)
|10–16 µM/L||75–120 Mg/dL|
|ZZ (2 abnormal copies)||2.5–7 µM/L||20–45 Mg/dL|
|NULLNULL (2 nonfunctional copies)||0 µM/L||0 Mg/dL|
There are many types of abnormal AAT genes. The most common abnormal AAT genes are labeled S or Z. Normal genes are labeled M.
Even being a carrier for Alpha-1 may result in lung disease in adults and/or liver disease in infants, children, or adults. Learn more about what you can do in terms of:
Prolastin-C, Alpha1-Proteinase Inhibitor (Human) is for adults who have emphysema caused by inherited alpha1-antitrypsin deficiency. The effect of therapy with any alpha1-proteinase inhibitor (alpha1-PI) on pulmonary exacerbations and on the progression of emphysema in alpha1-antitrypsin deficiency has not been demonstrated in randomized, controlled clinical trials. PROLASTIN-C is not indicated as therapy for lung disease in patients in whom severe Alpha1-PI deficiency has not been established.
Prolastin-C may contain trace amounts of IgA. IgA deficient patients with antibodies against IgA should not receive Prolastin-C due to the risk of hypersensitivity.
The most common side effects during clinical trials with Prolastin-C were chills, a general feeling of being unwell, headache, rash, hot flush, and itching.
Prolastin-C is made from human plasma. Products made from human plasma may carry a risk of transmitting infectious agents, e.g., viruses, and, theoretically, the Creutzfeldt-Jakob disease (CJD) agent.
Please see accompanying Prolastin-C Full Prescribing Information for complete prescribing details.
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.